Christine Weingart

Christine Weingart

Associate Professor, Microbiologist
Chair of Biology
Position Type
Faculty
Service
- Present
ALL AFFLIATIONS

Overview

Degree(s)
B.S., Mount Union College; Ph.D., Miami University

Learning & Teaching

Courses
  • Biology 210: Molecular Biology and Unicellular Life
  • Biology 315: General Microbiology
  • Biology 316: Virology
  • Biology 317: Diversity of Microorganisms
  • Biology 361/2: Directed Study
  • Biology 451/2: Senior Research
Academic Positions
  • Associate Professor, Department of Biology at Denison University, 2009-present
  • Assistant Professor, Department of Biology at Denison University, 2002 - 2008
  • Lecturer, Department of Microbiology at Miami University, 1997

Research

Research Overview
My goal is to find more effective ways to treat B. cenocepacia lung infections in cystic fibrosis patients. I use infection models to study how the bacterium Burkholderia cenocepacia causes disease and to use bacteriophages to block disease.
Research Details

Cornell University, Ithaca, New York

  • Post Doctorate Research Associate, Laboratory of Stephen C. Winans, 1999-2002

University of Cincinnati College of Medicine, Cincinnati, Ohio

  • Post Doctorate Research Associate, Laboratory of Alison A. Weiss, 1997-1999

Works

Publications
  • Peck, K*, Harkins, K*, Zhang, J*, Chosky, D*, and C. Weingart. Burkholderia cenocepacia phages reduce transmission comparable to disinfectants. In preparation.
  • Wijers*, C.D.M., Vagedes, R*, and C. Weingart. 2016. A novel method for investigating Burkholderia cenocepacia infections in patients with cystic fibrosis and other chronic diseases of the airways. BMC Microbiol. 16(1):200
  • Bingaman, C.*, Hoffman, C.*, Zelenkov, J.* and Y. Zhang*. 2016. You light up my life:Bioluminescent bacteria and anglerfish. Microbial Discovery Activity.
  • Merry, C.*, Perkins, M.*, Mu, L.*, Peterson, B.*, Weber, R.*, and C. L. Weingart. 2015. Characterization of a novel two-component system in Burkholderia cenocepacia. Cur. Microbiol. 70:556-61
  • Aukerman, B*., Esselburn, K.*, Freundlich, J.* and C. Mustillo.* 2010. Bacteria that help and hurt cows. Microbial Discovery Activity
  • Bhatt, S.* and C.L. Weingart . 2008. Identification of sodium chloride-regulated genes in Burkholderia cenocepacia. Cur. Microbiol. 56:418-422.
  • Weingart, C.L., C. E. White, S. Liu,Y. Chai, H. Cho, C. Tsai, Y. Wei, N. R. Delay*, A. Eberhard, and S. C. Winans. 2005. Direct binding of the purified quorum sensing regulator CepR of Burkholderia cenocepacia to two target promoters in vitro. Mol. Micro. 57:452-467.
  • Pappas, K. M., and C. L. Weingart., and S. C. Winans. 2004. Biochemical communication in proteobacteria: Biochemical and structural studies of signal synthases and receptors required for intercellular signaling. Mol. Microbiol. 53:755-769.
  • Weingart, C. L., P. S. Mobberley-Schuman, E. L. Hewlett, M. C. Gray, and A. A. Weiss. 2000. Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils. Infect. Immun. 68:7152-7155.
  • Weingart, C. L., W. A. Keitel, K. M. Edwards, and A. A. Weiss. 2000. Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults. Infect. Immun. 68:7175-7179.
  • Weingart, C. L. and A. A. Weiss. 2000. Bordetella pertussis virulence factors affect phagocytosis by human neutrophils. Infect. Immun. 68:1735-1739.
  • Lenz, D. H.*, C. L. Weingart and A. A. Weiss. 2000. Phagocytosed Bordetella pertussis fail to survive in human neutrophils. Infect. Immun. 68:956-959.
  • Weingart, C. L., G. Broitman-Maduro, G. Dean, S. Newman, M. Peppler, and A. A. Weiss. 1999. Fluorescent labels influence the phagocytosis of Bordetella pertussis by human neutrophils. Infect. Immun. 67:4264-4267
  • Weingart, C. L., and A. Morris Hooke. 1999. A nonhemolytic phospholipase C from Burkholderia cepacia. Curr. Microbiol. 38:233-238.
  • Weingart, C. L., and A. Morris Hooke. 1999. Regulation of expression of the nonhemolytic phospholipase C from Burkholderia cepacia. Curr. Microbiol. 39:336-341.

*denotes student co-author

Presentations
  • Peck, K*, Vagedes, R*, Zhang, J.* and C.L. Weingart. 2017. Burkholderia cenocepacia bacteriophages decontaminate surfaces and reduce pathogenesis. 115th Gen. Meet. Am. Soc. Microbiol.
  • Vagedes, R* and C.L. Weingart. 2017. Bacteriophage therapy application in a cystic fibrosis tissue culture model. Ohio Branch-ASM Meeting.
  • Harkins, K* and C.L. Weingart. 2015. Isolation and characterization of Burkholderia cenocepacia bacteriophages and their efficacy in a Lemma minor infection model. Ohio Branch-ASM Meeting. (Note: Kiira won the award for best undergraduate research presentation.)
  • Wijers, C.* and C.L. Weingart. 2015. A novel method for investigating Burkholderia cenocepacia infections in patients with cystic fibrosis and other chronic diseases of the airways. Ohio Branch-ASM Meeting
  • Peck, K.* and C.L. Weingart. 2014. Isolation and characterization of a Burkholderia cenocepacia specific bacteriophage. Ohio Branch-ASM Meeting
  • Coggins, N.* and C.L. Weingart. 2013. Isolation and identification of Burkholderia cenocepacia bacteriophages. Ohio Branch-ASM Meeting (Note: Nicole won the award for best undergraduate research presentation.)
  • Merry, C.*, Perkins, M.*, Mu, L.*, Eichner, S.*, Crabb, A.*, Peterson, B.*, Weber, R.*, and C. L. Weingart. 2010. A two-component system in Burkholderia cenocepacia influences protease, swimming, quorum sensing, and pathogenesis. 109th Gen. Meet. Am. Soc. Microbiol.
  • Foy, C.*, and C.L. Weingart. 2009. Investigation of selenite reduction in Burkholderia cenocepacia. 108th Gen. Meet. Am. Soc. Microbiol.
  • Perkins, M.*, Crabb, A.*, Peterson, B.*, Weber, R.* and C. L. Weingart. 2008. Characterization of a putative gacSA two component system in Burkholderia cenocepacia. 107th Gen. Meet. Am. Soc. Microbiol.
  • Foy, C.* and C. L. Weingart. 2010. Examining the relationship between a two-component system and quorum sensing in Burkholderia cenocepacia. Ohio Branch-ASM Meeting.
  • Eichner, S*. and C.L. Weingart. 2010. Distribution of the gacA gene in the Burkholderia cepacia complex. Ohio Branch-ASM Meeting.
  • Foy, C.R.* and C. L. Weingart. 2009. Role of TolB in Selenite Reduction in Burkholderia cenocepacia. Ohio Branch-ASM Meeting.
  • Merry, C.* and C.L. Weingart. 2009. Characterization of GacS/GacA Two-Component System in Burkholderia cenocepacia. Ohio Branch-ASM Meeting.
  • Jaffri, S.* and C.L. Weingart. 2008. Characterization of tolB in Burkholderia cenocepacia. Indiana-Ohio Joint Branch ASM Meeting.
  • Jaffri, S.* and C.L. Weingart. 2007. Characterization of tolB in Burkholderia cenocepacia. Annual Biomedical Research Conference for Minority Students
  • Jaffri, S.* and C.L. Weingart. 2007. Complementation in Burkholderia cenocepacia of mutated tolB gene with wild type tolB gene. Ohio Branch ASM Meeting.
  • Crabb, A.* and C.L. Weingart. 2007. An examination of a putative GacA/GacS two component system as a regulator of virulence factors produced by Burkholderia cenocepacia. Ohio Branch ASM Meeting. (Note: Andrea won an award for best research presentation. She competed with undergraduate and graduate students.)
  • Bhatt, S.* and C. L. Weingart. 2005, Characterization of four hyperosmotically induced genes in Burkholderia cepacia. 104th Gen. Meet. Am. Soc. Microbiol.
  • Perkins, M.* and C.L. Weingart. 2005. Mutation of a potential gacSA two component system in Burkholderia cenocepacia. Ohio Branch ASM Meeting. (Note: Mike won the award for best undergraduate research presentation.)
  • Bhatt, S.* and C. L. Weingart. 2004, Isolation of hyperosmotically regulated genes in Burkholderia cepacia. 104th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L. 2004. Identification of a Putative gacSA two-component system in Burkholderia cepacia. 104th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L. 2003. Incorporating Quorum Sensing into the Undergraduate Microbiology Laboratory. 1-11, p. 11. 10th ASM Undergraduate Microbiology Education Conference.
  • Weingart, C. L. and S. C. Winans. 2001. Characterization of a quorum sensing system in Burkholderia cepacia. ASM Cell-Cell Communication Meeting.
  • Weingart, C. L. and S. C. Winans. 2001 Characterization of a quorum sensing system in Burkholderia cepacia. Infection and Pathobiology Forum. Cornell University.
  • Weingart, C. L., D. H. Lenz*, and A. A. Weiss. 1999. Phagocytosis of Bordetella pertussis by human neutrophils. Midwest Microbial Pathogenesis Meeting.
  • Lenz, D. H.*, C. L. Weingart, A. A. Weiss. 1999. Lack of survival of Bordetella pertussis following phagocytosis by human neutrophils. Physician Scientist Training Program Research Forum.
  • Weingart, C. L., G. E. Dean, S. L. Newman, and A. A. Weiss. 1999. Comparison of phagocytosis of FITC and GFP labeled Bordetella pertussis. 99th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L., S. Newman and A. A. Weiss. 1998. Effect of labeling treatments on phagocytosis of Bordetella pertussis. Midwest Microbial Pathogenesis Meeting.
  • Weingart, C. L., and A. A. Weiss. 1998. Effect of immune serum antibodies on phagocytosis of Bordetella pertussis. B-61, p. 65. Abstr. 98th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L., and A. Morris Hooke. 1998. Regulation of expression of Burkholderia cepacia phospholipase C. Microbial Pathogenesis Current and Emerging Issues Conference.
  • Weingart, C. L., and A. Morris Hooke. 1998. Regulation of expression of Burkholderia cepacia phospholipase C. B-12, p. 92. Abstr. 98th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L., and A. Morris Hooke. 1996. Purification and characterization of a phospholipase of Burkholderia cepacia. B-396, p. 223. Abstr. 96th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L., and A. Morris Hooke. 1995. Purification of a non-hemolytic phospholipase C from Burkholderia cepacia. B-266, p. 212. Abstr. 95th Gen. Meet. Am. Soc. Microbiol.
  • Weingart, C. L., M. K. Lonon, S. Karipedes, and A. Morris Hooke. 1994. Characterization of a non-hemolytic phospholipase C produced by Pseudomonas cepacia. B-38, p. 35. Abstr. 94th Gen. Meet. Am. Soc. Microbiol.

* denotes student co-author

Service

Professional Memberships
  • Ohio Branch American Society for Microbiology, Member (OBASM), 2003-present
  • American Society for Microbiology, Member, 1992-present

Other

Grants & Funding
  • Denison University Research Foundation Grant, 2013
  • Denison University Research Foundation Grant, 2008
Student Collaborations
  • Parnell Sheldon ’18, Senior research 2017-18
  • Anna Mankovich ’19, Early Experience Summer Scholar 2017, Directed study spring 2018
  • Kayleigh Humphries ’16, Directed study, Fall 2015
  • Ryan Vagedes ’17, Anderson Summer Scholar 2016; Senior research 2016-17
  • Jenny Zhang ’18, Anderson Summer Scholar 2016, 2017
  • Devon Chosky ’16, Anderson Summer Scholar 2015, Senior research 2016
  • Madison Kavanaugh ’16, Anderson Summer Scholar 2015, Senior research 2016
  • Kiira Harkins ’16, Directed study, Spring 2015; Senior research 2015-16. OBASM Paul N. Hudson Research Awardee Spring 2016
  • Chris Weijers ’16, Directed study, Spring 2015; Senior research 2015-16
  • Meghan Diefenbacher ’15, Directed study, Spring 2015
  • Dennis Tan, Directed study, Fall 2014
  • Yuqing Liang, Directed study, Fall 2014 and Spring 2015
  • Sarah Winnicki, Directed study, Fall 2014
  • Christian Wijers ’15, Directed study, Spring 2014; Senior research 2014-15
  • Kira Harkins ’15, Directed study, 2013-2014; Senior research 2014-15
  • Hannah Roodhouse ’17, Directed Study, Spring 2014
  • Kristin Peck ’14, Anderson Summer Scholar, 2013; Senior research 2013-14
  • Dennis Tan ’15, DURF research assistant, 2013
  • Nicole Coggins ‘13, Senior research, 2012-13. OBASM Paul N. Hudson Research Awardee Spring 2013
  • Abby Kerbaugh ‘13, Directed study, Spring 2013
  • Herb Porter ‘13, Directed study, Fall 2012
  • Julia Shneyderman ‘13, Directed study, Fall 2012
  • Jamieson Weaver, Granville High School junior, Summer 2012
  • Meghan Diefenbacher, ’15, Anderson Summer Scholar, 2012
  • Jessica Wilson ’11, Anderson Summer Scholar, 2011; Directed study 2011-12
  • Kasi Eastep ‘11, Anderson Summer Scholar, 2011
  • Lin Mu ‘12, Directed study spring 2010; Directed study 2011
  • Sarah Eichner, Anderson Summer Scholar, 2009; Senior Research 2009-10
  • Chase Foy ’10, Denison University Research Foundation research assistant, Summer 2008; Directed Study Fall 2008; Senior Honors’ Research 2009-2010
  • Callie Merry ’09, Bowen Scholar Summer 2008; Senior Honors’ Research 2008-09
  • Sarah Jaffri ’08, Hughes Early Research Experience Scholar Summer 2006; Anderson Summer Scholar 2007, Senior Research Fall 2007-08.
  • Bridget Peterson ’08, Anderson Summer Scholar 2007, Senior Honors’ Research, Fall 2007; Spring 2008
  • Becky Weber ’08, Senior Honors’ Research, Fall 2007-Spring 2008
  • Andrea Crabb ’07, Anderson Summer Scholar 2007, Senior Honors’ Research, Fall 2006-Spring 2007. OBASM Paul N. Hudson Research Awardee Spring 2007
  • Kate Seymour ’07, Anderson Summer Scholar 2006, Senior Honors’ Research, Fall 2006-Spring 2007.
  • Cora Walsh ’06, Senior Honors’ Research, Fall 2005-Spring 2006. Co-advisor with Kent Maynard
  • Melissa Taylor, Directed Study Spring 2006.
  • Mike Perkins’05, Anderson Scholar, Summer 2004; Senior Research, Fall 2004-Spring 2005. OBASM, Undergraduate Research Awardee, Spring 2005.
  • Shantanu Bhatt‘04, Hughes Early Research Experience Scholar Summer 2003; Directed Study, Fall 2003; Anderson Summer Scholar 2004; Senior Honors’ Research, Spring 2004 to Fall 2004.
  • Tiffany Miller ’04, Directed Study Fall 2003, Spring 2004.

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