Katherine Lindsay '20 awarded Battelle grant

Staff News

In Summer 2019, biology major and chemistry minor Katherine Lindsay ’20 was granted $4157.00 to cover costs associated with a research internship in Germany.

Lindsay notes:

“My undergraduate work at Denison centers around a natural science focus, which has inculcated in me a passion for exploration into research topics with challenging questions pertaining to molecular biology. I would like to pursue a Cancer and Cell Biology graduate program after my studies at Denison.”

She adds:

“Since summer 2017, I have been working in Dr. Lina Yoo’s lab dedicated to investigating tumor suppressors through a competitive scholarship awarded by Denison University. I am motivated not only to comprehend the fundamental concepts behind the science, but also to develop a solution.

“I have an interest in not only the etiology of cancer but also the experimentation involved. In my own lab, I am studying an array of potential tumor suppressors and pan of my work has involved successfully engineering knockout plasmids via the CRISPR/Cas9 tool and establishing stable transfected colonies in order to determine gene functionality. I work from 5-10 hours a week in addition to my academic work on my independent research to continue the progress from the past summer.

“Investigating the rise of tumorigenesis appeals to me and I’m curious to investigate the expression of Dkk3 of these transgenic mice. I have previously worked on characterizing Kidney Fibrosis in a mouse model and I’m curious to know if the JAK-STAT inflammation pathway could be potentially implicated, as chronic pancreatitis can be a precursor to PDAC.

“Additionally, I wonder if it would be feasible to culture pancreatic cancer cells in hypo- or hyperglycemic conditions to elicit a kind of oxidative stress. I would hope to observe a change in the localization of RINTI as autophagy can be triggered by ER-stress. Furthermore, I’d be interested in examining the morphology of the mitochondria, as mitochondrial clearance via autophagy is a necessary process for cellular fitness given the established importance of RINTI homeostasis.”

Posted Date 
Thursday, April 30, 2020

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