Position Type 
Faculty
Service 
1994 - Present
All Affiliations 

Overview

Degree(s) 
B.S., University of Wisconsin, Madison; Ph.D., University of California, Berkeley

Learning & Teaching

Academic Positions 
  • Professor, Department of Biology at Denison University, 2007 to present
  • Chair, Department of Biology at Denison University, 2002 to 2007
  • Associate Professor, Department of Biology at Denison University, 2000 to 2007
  • Grant Reviewer, Developmental Neurobiology at National Science Foundation, 2001 and 2004
  • External Reviewer for faculty promotions, ex. Department of Political Science at Pomona College (2007), Kalamazoo College (2001)
  • Ad Hoc Manuscript Reviewer, ex. Department of Political Science at Genetics, Oncogene
  • Student-Teacher Referee, Department of Education at Denison University, 2001
  • Assistant Professor, Department of Biology at Denison University, 1994 - 2000
  • Teaching Assistant, Department of Molecular and Cell Biology at University of CA-Berkeley

Research

Overview 
Axon guidance — I am using second-site modifier genetic screens in Drosophila to identify components of tyrosine kinase signaling pathways. Once novel genes are identified, they are characterized through classical and molecular genetic techniques.

Works

Publications 
  • Smith, JA and Liebl, EC. 2006. Identification of the Molecular Lesions in Alleles of the Drosophila Abelson Tyrosine Kinase. Drosophila Information Service. v. 88 p. 20-23
  • Forsthoefel, DJ, Liebl, EC, Kolodziej, PA, Seeger, MA. 2005. The Abelson tyrosine kinase, the Trio GEF, and Enabled interact with the Netrin receptor Frazzled in Drosophila. Development. v. 132 p. 1983-1994
  • Liebl EC, Rowe RG, Forsthoefel DJ, Stammler AL, Schmidt ER, Turski M, Seeger MA. 2003. Interactions between the secreted protein Amalgam, Amalgam's transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding. Development. v. 130 no. 14 p. 3217-3226
  • Liebl EC, DJ Forsthoefel, LS Franco, SH Sample, JE Hess, JA Cowger, MP Chandler, AM Shupert and MA Seeger. 2000. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron. v. 26 p. 107-118
  • Liebl EC. 1999. Molecular Characterization of the Insertion Site in Eight P-Insertion Lines from the Kiss Collection. Drosophila Information Service. v. 82 p. 79-81
  • Liebl, EC, DJ Forsthofel, ER Schmidt, M Turski, KB Markham and MA Seeger. Mutational analysis of amalgam provides insights into Abl-dependent, Neurotactin-mediated adhesion and axon pathfinding in Drosophila. Genetics.
  • Hu, W-L, G Minihan, GR Buckles, H Hayter, EC Liebl, M-C Ramel and FN Katz. 2002. Dachs encodes an unconventional myosin that is required for segmentation and morphogenesis during limb development in Drosophila. Developmental Biology.
  • Liebl EC, DJ Forsthoefel, LS Franco, SH Sample, JE Hess, JA Cowger, MP Chandler, AM Shupert and MA Seeger. 2000. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding. Neuron. v. 26 p. 107-118
  • Liebl EC. 1999. Molecular Characterization of the Insertion Site in Eight P-Insertion Lines from the Kiss Collection. Drosophila Information Service. v. 82 p. 79-81
  • Liebl EC. 1998. Testing for mutagens using fruit flies. The American Biology Teacher. v. 60 p. 1-5
  • Comer AR, EC Liebl and FM Hoffmann. 1995. Can clues to the molecular defects in chronic myelogenous leukemia come from genetic studies on the Abelson tyrosine kinase in fruit flies?. The Journal of Laboratory and Clinical Medicine. v. 125 p. 686-691
  • Gertler FB, AR Comer, JL Juang, SM Ahern, MJ Clark, EC Liebl and FM Hoffmann. 1995. enabled, a dosage-sensitive suppresser of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3-domain binding properties. Genes and Development. v. 9 p. 521-533
  • Liebl EC and FM Hoffmann. 1994. Growth factors and signal transduction in Drosophila. M. Nilsen-Hamilton, ed., Growth Factors and Signal Transduction in Development. p. 165-174
  • Liebl EC, LJ England and GS Martin. 1993. Reactivation of host-dependent src kinase activity by coexpression with a heterologous tyrosine kinase. Virology. v. 195 p. 265-267
  • Liebl EC, LJ England, JE DeClue and GS Martin. 1992. Host range mutants of v-src: Alterations in kinase activity and substrate interactions. J. Virol. v. 66 p. 4315-4324
  • Liebl EC and GS Martin. 1992. Intracellular targeting of pp60src expression: Localization to adhesion plaques is sufficient to transform chicken embryo fibroblasts. Oncogene. v. 7 p. 2417-2428
  • Young JC, EC Liebl and GS Martin. 1998. A host-dependent temperature sensitive mutant of Rous sarcoma virus: Evidence for host factors affecting transformation. Virology. v. 166 p. 561-572
  • Pai JK, EC Liebl, CS Tettenborn, FI Ikegwuonu and GC Mueller. 1987. 12-O-tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol. Carcinogenesis. v. 8 p. 173-178
Presentations 
  • Liebl EC, CL Baldyga, LL Bickle, A Bishop, KE Dean, M Kopeke, RR Manohar, JR McCall, J McCroskey, JA Smith, MA Seeger. 2007. A screen for dominant enhancers of a trio mutant phenotype. 48th Annual Drosophila Research Conference. Philadelphia, PA
  • Liebl EC, CL Baldyga, LL Bickle, M Kopeke, RR Manohar, JR McCall, JA Smith, MA Seeger. 2005. A screen for dominant enhancers of a trio mutant phenotype. Cold Spring Harbor Meeting on Neurobiology of Drosophila. Cold Spring Harbor, NY
  • Liebl, EC, RG Roew, DJ Forsthoefel, AM Stammler, MA Seeger. 2003. Identification of neurotactin as a dominant enhancer of the Abelson tyrosine kinase mutant phenotype. 44th Annual Drosophila Research Conference. Chicago, IL
  • Liebl, EC. 2003. Amalgam functions as a dominant enhancer of the Abl mutant phenotype . Science Lecture Series. Ohio Wesleyan University, OH
  • Liebl, EC., ER Schmidt, DJ Forsthoefel, SC Howard, MA Seeger. 2001. Identification of amalgam as a dominant enhancer of the Abelson tyrosine kinase phenotype. 42nd Annual Drosophila Research Conference. Washington, DC
  • Liebl EC. 2001. Gaining insights into axonal pathfinding: combining genetics and cell biology nto an interesting amalgam. Kenyon College Biology Lecture Series. Gambier, OH
  • Forsthoefel DJ, ER Schmidt, S Howard, MA Seeger, EC Liebl. 2000. Trio, a cytoplasmic GEF, and Amalgam, a secreted member of the immunoglobulin superfamily, exhibit dosage-sensitive genetic interactions with the Abelson tyrosine kinase and function in Drosophila axon guidance pathways. Axon Guidance & Neural Plasticity Meeting. Cold Spring Harbor, NY
  • Liebl EC. 1999. Signal transduction in the developing CNS: Reciprocal genetic interactions between the Abl tyrosine kinase and a guanine-nucleotide-exchange factor. Ohio State Molecular, Cellular and Developmental Biology Seminar Series. Columbus, OH
  • Korn JM* and EC Liebl. 1999. Isolating Dominant Enhancers of the two-thirds-trio Mutant Phenotype. Genetics Society of America's Midwest Drosophila Conference. Allerton Park, IL
  • Schmidt E, SC Howard R Perala, EC Liebl. 1999. Fine Mapping of the M109 Gene. Genetics Society of America's Midwest Drosophila Conference. Allerton Park, IL
  • Liebl EC, DJ Forsthoefel, SH Sample, LS Franco, JE Hess, MP Chandler, JA Cowger, AM Jackson, MA Seeger. 1999. Dosage-Sensitive Interactions Between two-thirds-trio, a Putative Guanine-Nucleotide-Exchange Factor, the Abl Tyrosine Kinase, enabled and failed-axon-connections. Cold Spring Harbor Meeting on Neurobiology of Drosophila. Cold Spring Harbor, NY
  • Liebl EC, SH Sample, LS Franco, JE Hess, JA Cowger, AM Jackson, DJ Forsthoefel, MA Seeger. 1999. Dosage-Sensitive, Reciprocal Genetic Interactions Between a Putative Guanine-Nucleotide-Exchange Factor and the Abl Tyrosine Kinase. Fifteenth Annual Meeting on Oncogenes and Tumor Suppressors: Signal Transduction and Cell Cycle Regulation in Cancer. Fredrick, MD
  • Liebl EC. 1998. These Nobels Were Dynamite: Using the Genius of Morgan, McClintock and Mullis to Clone a Gene. Biology Symposium. The College of Wooster, OH
  • Liebl EC. 1998. The Last of the Positional Cloners. I-71 Cellular and Molecular. Kenyon College, OH
  • Liebl EC, JE Hess, FM Hoffmann. 1997. Characterization of M89: A Gene Redundant to the Abl Tyrosine Kinase. Genetics Society of America's Midwest Drosophila Conference. Allerton Park, IL
  • Liebl EC and T Schuh. 1996. Using Xenopus and Drosophila in Your Developmental Biology Lab - A Practical Guide. 55th Annual Society for Developmental Biology Symposium. Nashville, TN
  • Liebl EC. Tubby Flies. 1995. CNS Axons and Leukemia: Using Genetics to Unravel a Biological Problem. Denison Scientific Association. Granville, OH
  • FB, AR Comer, J-L Juang, SM Ahern, MJ Clark, EC Liebl, FM Hoffmann. 1995. enabled, a Suppresser of Mutations in the Drosophila Abl Tyrosine Kinase, Encodes an Abl Substrate with SH3-domain Binding Properties. 54th Annual Society for Developmental Biology Symposium. San Diego, CA
  • Liebl EC, FB Gertler, FM Hoffmann. 1994. Interactions with dachs May Link Abl Tyrosine Kinase-Mediated Signal Transduction with Cellular Adhesion. 53rd Annual Society for Developmental Biology Symposium. Madison, WI
  • Liebl EC, FB Gertler, FM Hoffmann. 1994. Genetic Interactions with dachs May Serve to Link Abl Tyrosine Kinase-Mediated Signal Transduction with Cellular Adhesion. 35th Annual Drosphila Research Conference. Chicago, IL
  • Liebl EC, FB Gertler, KK Hill, FM Hoffmann. 1993. Genetic Modifiers of the abl Mutant Phenotype. 9th Annual Meeting on Oncogenes. Fredrick, MD
  • Liebl EC, KK Hill, FB Gertler, FM Hoffmann. 1993. Second Site Suppressors of the abl Mutant Phenotype. 34th Annual Drosophila Research Conference. San Diego, CA
  • Liebl EC, KK Hill, FB Gertler, MJ Clark, M Visalli, FM Hoffmann. 1992. Identification of Second Site Modifiers of the abl Mutant Phenotype. 33rd Annual Drosophila Research Conference. Philadelphia, PA
  • Liebl EC, LJ England, GS Martin. 1990. Insertion/Deletion Mutagenesis of v-src: Effects on Intracellular Location and Protein-Tyrosine Phosphorylation. Sixth Annual Meeting on Oncogenes. Fredrick, MD
  • Liebl EC, LJ England, JE DeClue, GS Martin. 1989. Intracellular Localization of v-src: Effects on Fibroblast Transformation.. Fifth Annual Meeting on Oncogenes. Fredrick, MD
  • Liebl EC and J Pai. 1986. Phorbol Esters Induce the Synthesis of Phosphatidyl Alcohols, a Unique Class of Phospholipids. McArdle Chemical Carcinogenesis Seminar. Madison, WI
  • Liebl EC, K.E. Dean, A.R. Fields, M. J Geer, E.C. King, B. T. Lynch, K.C. Palozola, E.M. Steenkiste, Y. Zhang. 2012. Characterizing M9.17, a strong dominant enhancer of the trio mutant phenotype. . Given at the 71st Annual Meeting of the Society for Developmental Biology. Montreal, Canada,
  • Liebl EC, A.R. Fields, M. J Geer, L.J. Korbel, B. T. Lynch, K.C. Palozola. 2011. Characterizing M9.17, a strong dominant enhancer of the trio and abl mutant phenotypes.. Given at the 53rd Annual Drosophila Research Conference. San Diego , CA
  • Liebl EC, M. J Geer, B. T. Lynch, K.C. Palozola. 2010. Characterizing dominant enhancers of a trio mutant phenotype.. Given at the 52nd Annual Drosophila Research Conference. Washington , DC
  • Palozola KC, O. Uguru, K.E. Dean, R.R. Manohar, J.R. McCall, J.A. Smith and E.C. Liebl . 2008. Dissecting signal transduction networks involving the Abl tyrosine kinase and the Trio guanine nucleotide exchange factor.. Given at the first annual McArdle Laboratory Research Symposium. Madison , WI
  • Liebl EC. 2008. Dosage-sensitive genetic interaction affecting axon guidance.. Given to the University of Toledo Biology Department. Toledo , OH

Other

Honors & Awards 
  • Richard Lucier Endowed Professorship in recognition of outstanding teaching and scholarship. August 2007 - present
  • National Institutes of Health Academic Research Enhancement Award (AREA) Grant, “Understanding Trio and Abl in Drosophila Axon Guidance Through Genetic Modifiers” (PI; 1R15HD059924-01); $196,312; 8/2009 to 8/2012.
  • Denison University Research Foundation Award, “A Systematic Search for Genetic Interactions Affecting Nervous System Development Involving the Abl Kinase and the Trio Guanine-Nucleotide-Exchange Factor”, $10,967, 2008-2009
  • Participant in the Faculty Summer Institute on the Ethical, Legal and Social Implications of the Human Genonome Project sponsored by the Dartmouth College Institute for the Study of Applied and Professional Ethics. June, 2004 at Howard University, Washington D.C.
  • National Science Foundation Grant, “Investigation of the integrated roles of Abl, Trio, and Neurotactin in axon outgrowth” (co-PI; NSF 0344053); $240,000; 2004-2007
  • R. C. Good Fellowship, Denison University, 2001
  • National Science Foundation Grant, “Genetic and Cell Biological Characterization of Trio and Amalgam: Two New Enhancers of Abl” (co-PI); $341,752; 2001-2004
  • Andrew W. Mellon Foundation, Collaboration with Technology Grant (PI); $21,216 2000-2001
  • Faculty Professional Development Award, Denison University, 2000
  • Denison University Research Foundation Award, “Fine Mapping and Cloning of the Fruit Fly M109 Gene”, $3,534, 1999-2000
  • Faculty Professional Development Award, Denison University, 1999
  • Junior Faculty Fellowship, Denison University, 1998
  • National Institutes of Health Academic Research Enhancement Award (AREA) Grant, “Probing Drosophila Abelson Tyrosine Kinase with Genetics” (PI); $98,182; 1996-2000.
  • Faculty Professional Development Award, Denison University, 1995
  • Damon Runyon-Walter Winchell Cancer Research Postdoctoral Fellowship, 1991-1994
  • Outstanding Graduate Student Instructor, University of California, 1988
  • National Science Foundation Graduate Fellowship Honorable Mention, 1987
  • Regents Fellowship, University of California, 1986
  • Honors Degree in Molecular Biology, University of Wisconsin, 1985
  • Trewartha Honors Undergraduate Research Grant, University of Wisconsin, 1984
Student Collaborations 

Senior Thesis Advised

  • Localizing dominant enhancers of the trio mutant phenotype and structure/function assays of Neurotactin. Kathryn Elizabeth Dean, 2007*
  • Tyrosine phosphorylation of Trio by Abelson tyrosine kinase. Andrew Justin Bishop, 2007*
  • An investigation of axon pathfinding in the central nervous system of Drosophila through the molecular and genetic characterization of dominant enhancers of the trio mutant phenotype. Jenna Susanne McCroskey, 2007*
  • Investigating Neurotactin and localizing the dominant enhancers of the trio mutant phenotype. Rohan Raoul Manohar, 2006*
  • Study on Neurotactin and dominant enhancers of the trio mutant phenotype. Lindsay Lee Bickel, 2006*
  • Identification of protein:protein interactions of the intracellular domain of Neurotactin by biopanning of a phage display cDNA library. Timothy Ryan Heacock, 2004*
  • Axon pathfinding in the central nervous system of D. melanogaster: Determining enhancers of the trio mutantphenotype from a random mutagenesis screen. Morgan Rebecca Koepke, 2004*
  • Interactions with Nrt: A yeast two-hybrid assay. Brant Lloyd Eutzy, 2003*
  • Amalgam and neurotactin are dosage-sensitive genetic modifiers of the Abl tyrosine kinase mutant phenotype. R. Grant Rowe, 2003*
  • The development of the central nervous system of Drosophila melanogaster: Potential interactions with Trio and Neurotactin. Kara Beth Markham, 2001*
  • Localization and characterization of the M109 mutation: A new allele of the Drosophila amalgam gene. Erica R. Schmidt, 2000*
  • Isolation of enhancers of the trio mutant phenotype. Jay Korn, 2000
  • Testing the effectiveness of two cryoprotectants (glycerol and ethylene glycol) and two freezing methods (dry ice block freezing and controlled rate freezing) in the cryopreservation of domestic felid spermatozoa. Katherine A. Beltaire, 1999*
  • M89: Transposon mutagenesis and recombination with fax. Lara S. Franco, 1999
  • Mycobacteriophage L5: Investigation of the integration complex and further characterization of the mIHF binding site. J. Michelle Kahlenberg, 1998*
  • Generation and characterization of gamma-ray generated M89 alleles. Matthew P. Chandler, 1998
  • Fine localization and characterization of the M89 gene in Drosophila melanogaster. Jon E. Hess, 1998*
  • Deficiency and meiotic recombinant mapping of the Drosophila Abl interacting gene M109. N. Reid Perala, 1998*
  • Genetic experiments exploring the Abl:Disabled genetic interaction. James Pavelka, 1997.
  • The search for a suppressor of the enabled mutant phenotype. Jason A. Hoppe, 1997.
  • The mapping and characterization of the M89 mutation in the genome of Drosophila melanogaster. Jennifer A. Cowger, 1997*
  • Using Drosophila genetics to study signal transduction by the Abl tyrosine kinase. Susan C. Howard, 1996*
  • The mapping and characterization of the M89 mutation in Drosophila. Angela M. Jackson, 1996*
  • Detection of a polymorphic microsatellite in the 21-hydroxylase gene region of the horse. Jennifer J. Carlisle, 1995*

* Denotes an honors thesis