Lina Yoo

Lina Yoo

Associate Professor
Chair of Biology
Position Type
- Present
Cell Biologist
B.S., Duke University; Ph.D., Washington University

Learning & Teaching

  • Biol 210 Molecular Biology and Unicellular Life
  • Biol 341 Immunology
  • Biol 345 Eukaryotic Cell Biology
Academic Positions
  • Associate Professor, Department of Biology at Denison University, 2012-present
  • Assistant Professor, Department of Biology at Denison University, 2005-2012
  • Postdoctoral Research Fellow, Department of Cell Biology at Harvard Medical School, 2000-2005
  • Teaching Assistant, Department of Biology at Washington University in St. Louis, St. Louis, MO, 1996


I am interested in the roles that microRNAs play in the development of cancer. My research focuses on identifying microRNA targets and studying the effects of altering these pathways on cellular behavior.


  • Yohn, NL., Bingaman, C., DuMont, A.L., and L.I. Yoo. (2011) Phosphatidylinositol 3’kinase, mTOR, and Glycogen synthase kinase-3B mediated regulation of p21 in human bladder carcinoma cells. BMC Urology 11:19. (24 August 2011)
  • Yoo, LI., D.W. Liu, S. Le Vu, R.T. Bronson, H. Wu, and J. Yuan. 2006. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 66:1929-1939.
  • Elliott, J, EB Goodhew, LT Krug, N Rafael, L Yoo, and SH Speck. 2004. Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B lymphoblastoid cell lines. J Virol. v. 78 p. 14062-5
  • Yoo, LI, J Woloszynek, S Templeton, and SH Speck. 2002. Deletion of Epstein-Barr virus regulatory sequences upstream of the EBNA gene promoter Wp1 is unfavorable for B-Cell immortalization. J Virology. v. 76 p. 11763-9
  • Yoo, LI, DC Chung, and J Yuan. 2002. LKB1—a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. v. 2 p. 529-35
  • Yoo, LI, and SH Speck. 2000. Regulation of EBNA gene expression. EBV Report. v. 7 no. p. 175-85
  • Yoo, L, and SH Speck. 2000. Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines. J Virol. v. 74 p. 11115-20
  • Kung, C, JT Pingel, M Heikinheimo, T Klemola, K Varkila, LI Yoo, K Vuopala, M Poyhonen, M Uhari, M Rogers, SH Speck, T Chatila, and ML Thomas. 2000. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. v. 6 p. 343-5
  • Kim, SW, TL Ortel, MA Quinn-Allen, L Yoo, L Worfolk, X Zhai, BR Lentz, and WH Kane. 1999. Partial glycosylation of asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex. Biochemistry. v. 38 p. 11448-54
  • Yoo, LI, M Mooney, MT Puglielli, and SH Speck. 1997. B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1. J Virol. v. 71 p. 9134-42
  • Weck, KE, ML Barkon, LI Yoo, SH Speck, and HW Virgin IV. 1996. Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus. J Virol. v. 70 p. 6775-80
  • Yoo, LI. 2013. Signaling in cancer development: stop or go? Ohio Wesleyan University Science Lecture Series. Delaware, OH
  • Yoo, LI. 2012. PTEN/PI3-kinase signaling and bladder cancer. Southern Illinois University School of Pharmacy Seminar Series. Edwardsville, IL
  • Yoo, LI. 2010. Regulation of p21 in bladder cells. John Carroll University Chemistry Seminar series. University Heights, OH
  • Yoo, LI. 2007. Characterization of the role of Pten in urologic cancer. College of Wooster Biology Seminar series. Wooster, OH
  • Yoo, LI. and J. Yuan. 2007. Pten-mediated tumor suppression in murine bladder epithelium. Signaling in Cancer Meeting at the Case Comprehensive Cancer Center. Cleveland, OH
  • Yoo, LI. 2004. Characterization of mice conditionally deficient for Pten in urogenital epithelium. Society for Basic Urologic Research Meeting. Savannah, GA
  • Yoo, LI, D Liu, R Bronson, H Wu, and J Yuan. 2004. Pten-mediated tumor suppression in murine bladder epithelium. Cancer Genetics & Tumor Suppressor Genes Meeting. Cold Spring Harbor, NY
  • Yoo, LI, S LeVu, R Verman, H Wu, R Bronson, and J Yuan. 2003. Characterization of mice conditionally deficient for PTEN in urogenital epithelium. The Beatson International Cancer Conference. Glasgow, Scotland
  • Yoo, LI, J Woloszynek, and SH Speck. 1999. Characterization of the EBV shared Cp/Wp enhancer. The 24th International Herpesvirus Workshop. Boston, MA
  • Yoo, LI, MA Mooney, and SH Speck. 1997. Regulation of EBV latency promoters by an EBNA2 responsive enhancer. The 22nd International Herpesvirus Workshop. San Diego, CA


Professional Memberships
  • American Society for Cell Biology


Grants & Funding
  • American Cancer Society Postdoctoral Fellowship Grant 2001-2004

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