Position Type 
Faculty
Service 
2005 - Present
All Affiliations 

Overview

Degree(s) 
B.S., Duke University; Ph.D., Washington University

Learning & Teaching

Courses 
  • Biol 210 Molecular Biology and Unicellular Life
  • Biol 341 Immunology
  • Biol 345 Eukaryotic Cell Biology
Academic Positions 
  • Associate Professor, Department of Biology at Denison University, 2012-present
  • Assistant Professor, Department of Biology at Denison University, 2005-2012
  • Postdoctoral Research Fellow, Department of Cell Biology at Harvard Medical School, 2000-2005
  • Teaching Assistant, Department of Biology at Washington University in St. Louis, St. Louis, MO, 1996

Research

Overview 
Tumor suppression and growth factor signaling — I am currently investigating the functions of several genes that are very highly mutated across multiple types of cancer. It is the goal of my research to understand the normal genetic functions within the cell so we can better understand how cancer develops.

Works

Publications 
  • Yohn, NL., Bingaman, C., DuMont, A.L., and L.I. Yoo. (2011) Phosphatidylinositol 3’kinase, mTOR, and Glycogen synthase kinase-3B mediated regulation of p21 in human bladder carcinoma cells. BMC Urology 11:19. (24 August 2011)
  • Yoo, LI., D.W. Liu, S. Le Vu, R.T. Bronson, H. Wu, and J. Yuan. 2006. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 66:1929-1939.
  • Elliott, J, EB Goodhew, LT Krug, N Rafael, L Yoo, and SH Speck. 2004. Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B lymphoblastoid cell lines. J Virol. v. 78 p. 14062-5
  • Yoo, LI, J Woloszynek, S Templeton, and SH Speck. 2002. Deletion of Epstein-Barr virus regulatory sequences upstream of the EBNA gene promoter Wp1 is unfavorable for B-Cell immortalization. J Virology. v. 76 p. 11763-9
  • Yoo, LI, DC Chung, and J Yuan. 2002. LKB1–a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. v. 2 p. 529-35
  • Yoo, LI, and SH Speck. 2000. Regulation of EBNA gene expression. EBV Report. v. 7 no. p. 175-85
  • Yoo, L, and SH Speck. 2000. Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines. J Virol. v. 74 p. 11115-20
  • Kung, C, JT Pingel, M Heikinheimo, T Klemola, K Varkila, LI Yoo, K Vuopala, M Poyhonen, M Uhari, M Rogers, SH Speck, T Chatila, and ML Thomas. 2000. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. v. 6 p. 343-5
  • Kim, SW, TL Ortel, MA Quinn-Allen, L Yoo, L Worfolk, X Zhai, BR Lentz, and WH Kane. 1999. Partial glycosylation of asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex. Biochemistry. v. 38 p. 11448-54
  • Yoo, LI, M Mooney, MT Puglielli, and SH Speck. 1997. B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1. J Virol. v. 71 p. 9134-42
  • Weck, KE, ML Barkon, LI Yoo, SH Speck, and HW Virgin IV. 1996. Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus. J Virol. v. 70 p. 6775-80
Presentations 
  • Yoo, LI. 2013. Signaling in cancer development: stop or go? Ohio Wesleyan University Science Lecture Series. Delaware, OH
  • Yoo, LI. 2012. PTEN/PI3-kinase signaling and bladder cancer. Southern Illinois University School of Pharmacy Seminar Series. Edwardsville, IL
  • Yoo, LI. 2010. Regulation of p21 in bladder cells. John Carroll University Chemistry Seminar series. University Heights, OH
  • Yoo, LI. 2007. Characterization of the role of Pten in urologic cancer. College of Wooster Biology Seminar series. Wooster, OH
  • Yoo, LI. and J. Yuan. 2007. Pten-mediated tumor suppression in murine bladder epithelium. Signaling in Cancer Meeting at the Case Comprehensive Cancer Center. Cleveland, OH
  • Yoo, LI. 2004. Characterization of mice conditionally deficient for Pten in urogenital epithelium. Society for Basic Urologic Research Meeting. Savannah, GA
  • Yoo, LI, D Liu, R Bronson, H Wu, and J Yuan. 2004. Pten-mediated tumor suppression in murine bladder epithelium. Cancer Genetics & Tumor Suppressor Genes Meeting. Cold Spring Harbor, NY
  • Yoo, LI, S LeVu, R Verman, H Wu, R Bronson, and J Yuan. 2003. Characterization of mice conditionally deficient for PTEN in urogenital epithelium. The Beatson International Cancer Conference. Glasgow, Scotland
  • Yoo, LI, J Woloszynek, and SH Speck. 1999. Characterization of the EBV shared Cp/Wp enhancer. The 24th International Herpesvirus Workshop. Boston, MA
  • Yoo, LI, MA Mooney, and SH Speck. 1997. Regulation of EBV latency promoters by an EBNA2 responsive enhancer. The 22nd International Herpesvirus Workshop. San Diego, CA

Service

Professional Memberships 
  • American Society for Cell Biology

Other

Grants & Funding 
  • American Cancer Society Postdoctoral Fellowship Grant 2001-2004