Dr. Ayana Hinton
Ph.D. in Biochemistry & Molecular Biology from Wayne State University, 2004
B.S. in Chemical Engineering from University of Michigan, 1996
Dr. Hinton teaches Eukaryotic Cell Biology, Cell & Molecular Biology, and other advanced courses in the Biology department.
Tufts University School of Medicine, Boston, MA
Post-doctoral Fellow, Laboratory of Dr. Michael Forgac, 2004-2010
Wayne State University
Pre-doctoral student, Laboratory of Dr. Sharon Ackerman, 1999-2004
University of Michigan
Undergraduate Independent Study Research, Laboratory of Dr. Levi Thompson, 1994-1996
Many proteins in the cell are large structures composed of several smaller polypeptides called subunits. These subunits must be properly assembled together to produce a functional protein. A better understanding of how large protein complexes are assembled could lead to new therapeutic targets for the treatment of many diseases including cancer. My research focuses on the assembly and targeting of the Vascuolar H+-ATPase. V-ATPases are essential for acidifying intracellular compartments. Several proteins have been identified that act as assembly factors for the V-ATPase and I am interested in determining how these factors interact with each other and with the V-ATPase to produce a functionally assembled protein. In addition, I am interested in determining what factors are necessary for targeting the V-ATPase to different cellular locations. The V-ATPase is normally found in the membranes of lysosomes, the Golgi Apparatus and vesicles. However, in certain cell types including kidney cells, neurons, and cancer cells, the V-ATPase is found in different cellular locations, including the plasma membrane, and this has functional significance for each type of cell. I am interested in identifying the proteins that interact with V-ATpases to determine their cellular localization.
Training in Education and Critical Research Skills Fellowship, 2007 – 2010
National Research Service Award Minority Fellowship, 2001 – 2004
Initiative for Minority Student Development Fellowship, 1999 – 2001